(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
epalrestat
CAS: 82159-09-9
Molecular Formula: C15H13NO3S2
(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid - Names and Identifiers
(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid - Physico-chemical Properties
| Molecular Formula | C15H13NO3S2 |
| Molar Mass | 319.4 |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Melting Point | 210-217 C |
| Boling Point | 516.8±60.0 °C(Predicted) |
| Flash Point | 266.4°C |
| Solubility | Easily soluble in tetrahydrofuran, more soluble in dimethylformamide, more difficult to dissolve in methanol, ethanol, ethyl acetate or acetone, less soluble in chloroform or ether, almost insoluble in water. |
| Vapor Presure | 1.66E-11mmHg at 25°C |
| Appearance | Deep red needle crystal |
| Color | yellow to orange |
| Merck | 14,3605 |
| pKa | 3.62±0.10(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| Refractive Index | 1.705 |
| MDL | MFCD00865484 |
| Physical and Chemical Properties | Dark red needle-like crystals, odor, bitter taste. Soluble in Tetrahydrofuran, more soluble in dimethylformamide, more difficult to dissolve in methanol, ethanol, ethyl acetate or acetone, difficult to dissolve in chloroform or ether, a few insoluble in water. Melting Point 210~217 °c (ethanol-water). |
(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid - Risk and Safety
| UN IDs | 2811 |
| WGK Germany | 3 |
| RTECS | XJ5131855 |
| Hazard Class | 6.1 |
| Packing Group | II |
(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid - Reference
| Reference Show more | 1. Zhang Mei, Li Chunxia, Wei Fang, et al. Protective effect of Dendrobium on human retinal microvascular endothelial cells induced by high glucose [J]. International Journal of Ophthalmology, 2019, 19(02):40-44. |
(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid - Nature
Open Data Verified Data
deep red needle-like crystal, odor, bitter taste. Melting Point 210~217 C (ethanol water). Soluble in Tetrahydrofuran, soluble in dimethylformamide, insoluble in chloroform or ether and other organic solvents, almost insoluble in water.
Last Update：2024-01-02 23:10:35
(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid - Preparation Method
Open Data Verified Data
The benzaldehyde, ethanol, sodium hydroxide and water mixture, drop plus propionaldehyde reaction, after treatment to get 2 A methyl 3 Phenyl acrolein. The carbon disulfide and dioxane are dissolved in concentrated ammonia water, under stirring, the sodium glycinate solution is added dropwise, the reaction is reacted, evaporated to dryness, the sodium chloroacetate solution is added, the reaction at room temperature is evaporated, water and concentrated hydrochloric acid are added, and the mixture is heated in a boiling water bath, the product was recrystallized, and 3 carboxymethyl Tannin was obtained. 3-carboxymethyl tannin, 2-methyl -3-phenyl acrolein, anhydrous sodium acetate and glacial acetic acid were refluxed together and treated to obtain epalrestat.
Last Update：2022-01-01 09:24:04
(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid - Use
Open Data Verified Data
The company was first listed in Japan in 1992. Aldose reductase inhibitor, for diabetic nerve terminal disorder caused by subjective symptoms, vibration sensory abnormalities, abnormal heartbeat change improvement.
Last Update：2022-01-01 09:24:04
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Product Name: Epalrestat Visit Supplier Webpage Request for quotationCAS: 82159-09-9
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Spot supply
Product Name: Epalrestat Visit Supplier Webpage Request for quotationCAS: 82159-09-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Epalrestat Visit Supplier Webpage Request for quotationCAS: 82159-09-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid
1628196-32-6
1628196-32-6